Table 2.

P450 8A1

Properties	References
Physiological substrates: Prostaglandins (PG) ( H1, H2, H3, G2), 15-keto-prostaglandin H2, 6-keto-prostaglandin F1α, 15-hydroperoxyeicosatetraenoic acid, 10-hydroperoxyoctadeca-8,12-dienoic acid	(Hecker and Ullrich 1989; Ullrich and Hecker 1990; Yeh et al. 2005; Chiang et al. 2006; Yeh et al. 2007; Cathcart et al. 2010; Nakayama 2010; Pan et al. 2016)
Function: Prostacyclin synthase, isomerization of prostaglandin H2 to prostacyclin (PGI2) (Fig. 3), inhibition of platelet activation and aggregation and induction of vasodilation. Believed to have anti-tumor effects as overexpression has been shown to be chemopreventive in a murine model of the disease, suggesting that the expression and activity of this enzyme may protect against tumor development.
Inhibition: Risk of essential hypertension, myocardial infarction and cerebral infarction (Chiang et al. 2006)
Inhibitors:
Drugs:
Actinomycin D a (Camacho et al. 2008)
Cycloheximide a (Camacho et al. 2008)
Cyclosporine a (Sharanek et al. 2015)
Miconazole, clotrimazole b (Yeh et al. 2005)
Minoxidil b (Yeh et al. 2005; Li et al. 2008)
Rofecoxib c (Griffoni et al. 2007)
Simvastatin a (Skogastierna et al. 2013)
Tranylcipromine b (Ding et al. 2002)
Other compounds:
Imidazole derivatives (4-phenylimidazole, 1-phenylimidazole, 1-benzylimidazole) b (Yeh et al. 2005)
U46619, U51605, or U44069 (PGH2 analogues) b (Wada et al. 2004; Yeh et al. 2005; Li et al. 2008; Chao et al. 2011)
Induction: Enhanced activity in tumor cells, potential anti-neoplastic and chemopreventive activity
Inducers:
Natural compounds:
13-cis-Retinoic acid, 9-cis-retinoic acid, all-trans- retinoic acid d (Camacho et al. 2008)
13-cis-Retinoic acid, 9-cis-retinoic acid, all-trans- retinoic acid d (Camacho et al. 2008)
Curcumin d (Tan et al. 2011)
Grape seed procyanidin extract d (Mao et al. 2016)
13-cis-Retinoic acid, 9-cis-retinoic acid, all-trans- retinoic acid d (Camacho et al. 2008)
Physiological compounds:
17β-Estradiol d (Korita et al. 2004)
Physiological condition:
Hypoxia e (Camacho et al. 2011; Wang et al. 2013)
Pregnancy d (Okahara et al. 1998)
Shear stress e (Korita et al. 2002)

Footnotes:

^aReduced/suppressed mRNA and/or protein level/expression and activity

^bCompetitive inhibition, ligand binding

^cDecreased/suppressed/inhibited activity/product formation

^dUp-regulation of biosynthesis, increased expression of protein

^eIncreased transcription/mRNA/protein expression/levels /and/or catalytic activity