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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Drug Metab Rev. 2018 Aug;50(3):256–342. doi: 10.1080/03602532.2018.1483401

Table 21.

P450 27C1

Properties References
Natural substrates: all-trans Retinol (vitamin A1), all-trans retinal and all-trans retinoic acid, 11-cis-retinal, all-trans retinol acetate (Vahlquist 1980; Törmä and Vahlquist 1985; Kramlinger et al. 2016; Pan et al. 2016; Johnson et al. 2017)

Function: Retinoid 3,4-desaturase, oxidation of all-trans retinol to 3,4-didehydroretinol (vitamin A2) (Figs. 21, 24)
Inhibitorsa:
Drugs:

Acitretin, arotenoid Ro 13–7410, 4-(N-hydroxyphenyl)retinamide, ketoconazole (Törmä et al. 1991)

Natural product:

13-cis-Retinoic acid (Rollman et al. 1993; Törmä et al. 1991)
Citral (Törmä et al. 1991)
Inducersa:

Physiological compound:

Cellular retinoid-binding protein (Andersson et al. 1994)

Physiological condition amd illnesses:

Squamous cell carcinoma and keratoacanthoma (Vahlquist et al. 1996)
UV light exposure (UVA, UVB) (Tafrova et al. 2012)

Footnote:

a

Mechanisms have not been investigated. All cited studies were only done at a cellular activity level before the assignment of P450 27C1.