Table 1.

Novel Expression Trait Associations for Genes Located in Genomic Loci not Previously Reported for Age at Natural Menopause.

Region	Gene	Model	Type	Z Score	P Valuea	R 2b
1q42.12	EPHX1	Hypothalamus	Protein	−4.80	1.61 × 10−6	0.02
5p15.31	CTD-2044J15.2	Ovary	LncRNA	−5.05	4.53 × 10−7	0.01
11q14.1	RP11-452H21.1	Hypothalamus	LncRNA	−4.91	9.27 × 10−7	0.04
19p12	CTB-175P5.4	Hypothalamus	LncRNA	4.69	2.69 × 10−6	0.33

Abbreviations: Protein, protein coding genes; lncRNA, long noncoding RNA genes.

^a P value derived from association analyses, with P ≤ 3.09 × 10⁻⁶ considered statistically significant based on Bonferroni correction of 16 164 tests (0.05/16 164).

^b R ²: Prediction performance derived using GTEx data.