Table 3.
Associations with antidepressants presented for all 292 T1D patients and gender specifically
| Antidepressants | ||||||||
|---|---|---|---|---|---|---|---|---|
| All N = 292 |
Men N = 162 |
Women N = 127 |
||||||
| COR | P | AOR | P a | AOR | P a | AOR | P a | |
| Gender (women) | 1.4 (0.6–3.3) | 0.44 | 1.3 (0.5–3.5) | 0.61 | – | – | – | – |
| Age (per year) | 1.04 (1.0–1.1) | 0.068 | 1.01 (0.96–1.07) | 0.59 | 1.00 (0.93–1.08) | 0.89 | 1.03 (0.96–1.10) | 0.42 |
| Diabetes duration (per year) | 1.02 (0.99–1.06) | 0.19 | – | – | 1.04 (0.99–1.10) | 0.11 | – | – |
| Depression (HADS ≥8p) | 9.6 (3.7–24.6) | < 0.001 | 10.6 (4.0–28.6) | < 0.001 | 10.6 (2.8–40.3) | 0.001 | 10.8 (2.4–48.5) | 0.002 |
| High HbA1c (> 70 mmol/mol) | 2.7 (1.1–6.3) | 0.026 | 1.4 (0.5–3.8) | 0.46 | – | – | 2.8 (0.7–11.1) | 0.15 |
| Total cholesterol (per mmol/l) | 0.98 (0.6–1.5) | 0.92 | – | – | – | – | – | – |
| Triglycerides (per mmol/l) | 1.1 (0.7–1.8) | 0.72 | – | – | – | – | – | – |
| HDL-cholesterol (per mmol/l) | 0.8 (0.3–2.7) | 0.76 | – | – | – | – | – | – |
| LDL-cholesterol (per mmol/l) | 0.9 (0.5–1.6) | 0.81 | – | – | – | – | – | – |
| Hs-CRP e (per mg/l) | 1.1 (0.8–1.5) | 0.42 | – | – | – | – | – | – |
| Abdominal obesity b | 2.9 (1.2–7.2) | 0.024 | 2.7 (1.0–7.4) | 0.052 | – | – | 4.6 (1.2–18.3) | 0.029 |
| BMI (kg/m2) (4 weight classes) | – | 0.56 | – | – | – | – | – | – |
| SBP (per mm Hg) | 1.00 (0.96–1.03) | 0.81 | – | – | – | – | – | – |
| DBP (per mm Hg) | 1.05 (0.99–1.11) | 0.087 | 1.05 (0.98–1.12) | 0.14 | – | – | 1.08 (0.99–1.18) | 0.092 |
| Hypoglycemia | – | > 0.99 | – | – | – | – | – | – |
| Smoking c | 0.4 (0.05–3.1) | 0.38 | – | – | – | – | – | – |
| Physical inactivity (< 0.5 h/week) | 1.8 (0.6–5.5) | 0.34 | – | – | – | – | – | – |
| Physical activity (4 levels) | – | 0.40 | – | – | – | – | – | – |
| LLD | 2.3 (1.0–5.7) | 0.063 | 2.3 (0.9–5.9) | 0.099 | – | – | – | – |
| AHD | 1.6 (0.7–3.8) | 0.28 | – | – | – | – | 2.3 (0.6–9.2) | 0.25 |
| Insulin and OAD | 1.6 (0.3–7.5) | 0.54 | – | – | – | – | – | – |
aMultiple logistic regression analysis (Backward: Wald). b N = 292/162/. All/men/women: N = 292/162/127; Hosmer and Lemeshow 0.370/0.787/0.54; Nagelkerke 0.210/0.160/0.274