Table 2.

Univariate and Multivariate Analysis for DFS and OS in ESCC Patients

	DFS		OS
	P value	HR (95% CI)	P value	HR(95% CI)
Univariate analysis
Sex	0.251	1.204 (0.877–1.655)	0.125	1.295 (0.931–1.802)
Age	0.994	1.001 (0.787–1.273)	0.982	0.997 (0.781–1.273)
Smoking	0.538	1.079 (0.846–1.377)	0.345	1.126 (0.880–1.440)
Tumor Size	0.166	1.185 (0.932–1.509)	0.113	1.218 (0.954–1.555)
Tumor Location	0.879	0.984 (0.799–1.212)	0.793	1.029 (0.831–1.274)
Differentiation	0.047	1.246 (1.003–1.549)	0.080	1.217 (0.977–1.518)
Vessel invasion	< 0.001	1.597 (1.228–2.076)	0.001	1.576 (1.205 2.061)
Nerve invasion	0.02	1.335 (1.046–1.703)	0.008	1.401 (1.094–1.793)
Clinical stage	< 0.001	2.856 (2.230–3.659)	< 0.001	2.899 (2.255–3.727)
MET FISH-positivity	0.001	2.114 (1.378–3.245)	0.002	2.002 (1.293–3.099)
Mutivariate analysis
Differentiation	0.376	1.106 (0.885–1.381)	–	–
Vessel invasion	0.425	1.119 (0.849–1.474)	0.455	1.113 (0.841–1.472)
Nerve invasion	0.506	1.089 (0.848–1.398)	0.269	1.153 (0.896–1.485)
Clinical stage	< 0.001	2.672 (2.061–3.465)	< 0.001	2.745 (2.111–3.569)
MET FISH-positivity	0.002	1.953 (1.271–2.999)	0.003	1.926 (1.243–2.983)