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Quantitation of AT100 immunoreactivity in ventral horn of the lumbar spinal cord of mice transgenic for full-length human P301S Tau as a function of time (5 animals/group). The values at 7–8 months (end stage) are taken as 100%. One-way ANOVA [F (4,20) = 66.17, p < 0.0001], followed by Tukey’s multiple comparison test between P20 mice and those aged 1, 2, 3 or 4 months; n.s. = not significant; *p < 0.05; ***p < 0.001; ****p < 0.0001. The results are expressed as means ± S.E.M
