Table 2.
Side effects and adverse reactions
| Study | Sample size | Side effects and adverse reactions in articles | ||||
|---|---|---|---|---|---|---|
| Maoto + NAIs | NAIs | Maoto | Maoto + NAIs | NAIs | Maoto | |
| Fukutomi 2005 [18] | 10 | 12 | None | None | ||
| Kubo 2007 [20] | 17 | 18 | 3 discontinued maoto | None | ||
| Taketani 2008 [22] | 40 | 145 | None | None | ||
| Tsuji 2011 [28] | 28 | 30 | 23 | 2 cases of diarrhoea, 2 cases of vomiting, 1 case of abdominal pain, 1 case of mental excitement |
1 case of diarrhoea, 1 cases of vomiting, 2 cases of abdominal pain, 2 cases of mental excitement, 1 case of dizziness, 1 case of periorbital oedema |
2 cases of diarrhoea, 1 case of vomit |
| Toriumi 2012 [30] | 89 | 124 | 58 | 11 discontinued treatment, 3 developed bacterial infection, 3 developed dehydration |
4 discontinued treatment, 1 changed treatment, 3 cases of abnormal behaviour, 1 developed bacterial infection, 3 developed dehydration |
5 discontinued treatment, 4 changed treatment, 3 developed bacterial infection |
| Kawamura 2007 [19] | 43 | 86 | 10 cases of abnormal behaviour | 9 cases of abnormal behaviour | ||
| Kawamura 2008 [21] | 47 | 125 | N/A | N/A | ||
| Kawamura 2009 [23] | 33 | 97 | N/A | N/A | ||
| Mori 2010 [24] | 40 | 19 | N/A | N/A | ||
| Nabeshima 2010 [25] | 8 | 12 | None | None | ||
| Suzuki 2011 [27] | 46 | 40 | N/A | N/A | ||
| Nabeshima 2012 [29] | 22 | 11 | 1 case of mild transaminase elevation, 1 discontinued treatment | 1 case of mild transaminase elevation | ||
NAI neuraminidase inhibitor; None, no reported side effects or adverse reactions in the arm, N/A not available
Sample sizes differ from those in Additional file 2: Table S1 for studies including loss-to-follow-up-participants in the analysis of side effects