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Receiver operating characteristic (ROC) curve for serum levels of histidine-rich glycoprotein (HRG) to discriminate between lung cancer patients and healthy subjects (a) and between IIIAB/limited disease and IV/extensive disease lung cancer (b). The blue line represents serum HRG level and the red line represents the reference line. The best cut-off point of HRG at 49.2 μg/ml (a) and 38 μg/ml (b) is marked, P < 0.0001.
