Alloxan-diabetic rats |
Depressive behavior |
N-Acetylcysteine and imipramine displayed antidepressant effects |
[48, 49] |
Diabetic rats |
Depressive behavior and oxidative stress |
Clonazepam and insulin reversed the depressive behavior and restored the antioxidant status |
[50, 52] |
STZ-diabetic rats |
Depressive behavior |
Hydrogen sulfide induced antidepressant effects |
[53] |
STZ-diabetic rats |
Depressive behavior, oxidative stress, and inflammation |
Metformin plus ascorbic acid reduced the depressive behavior and had antioxidant and anti-inflammatory effects |
[54] |
STZ-nicotinamide-diabetic rats |
Depressive behavior |
Ascorbic acid had antidepressant effects, reduced oxidative stress, and inflammation |
[55, 56] |
STZ-diabetic rats |
Depressive behavior |
Aloe vera displayed antidepressant, antioxidant, and antidiabetic effects |
[56] |
MDD and bipolar disorder patients |
Severity of symptoms was associated to glucose levels and the number of episodes to glucose toxicity |
— |
[63] |