Table 2.

Parameters for the model of the intracellular dynamics. Some parameters were estimated to fit the experimental data in Kretzschmar et al. (1999)

ParameterDescription		Value	References
$k_1^{+}$	Association (TGF-β)	4.44 nM−1 min−1,	(Schmierer et al. 2008; Chung et al. 2009)
$k_1^{-}$	Dissociation (TGF-β)	2.4 × 10−1 min−1	(Schmierer et al. 2008; Chung et al. 2009)
$k_2^{+}$	Association (EGF)	9.7 × 10−2 nM−1 min−1	(Hendriks et al. 2005)
$k_2^{-}$	Dissociation (EGF)	1.2 × 10−1 min−1	(Hendriks et al. 2005)
$k_T^{+}$	Association (Smad)	2.4 × 10−2 nM−1 min−1	(Chung et al. 2009)
$k_T^{-}$	Dissociation (Smad)	3.96 × 10−1 min−1	(Chung et al. 2009)
$k_T^0$	Phosphorylation (Smad)	2.4 × 10−1 min−1	(Chung et al. 2009)
$k_E^{+}$	Association (iEGFAM)	1.2 × 10−1 nM−1 min−1	Estimated
$k_E^{-}$	Dissociation (iEGFAM)	2.8 × 10−1 min−1	Estimated
$k_E^0$	Activation (aEGFAM)	8.15 × 10−3 min−1	Estimated
$k_B^{+}$	Association (aEGFAM:Smad)	3.0 × 101 nM−1 min−1	(Chung et al. 2009)
$k_B^{-}$	Dissociation (aEGFAM:pSmad)	9.6 × 10−1 min−1	(Chung et al. 2009)
k A	Inactivation (aEGFAM)	1.7 × 10−1 min−1	Estimated
k S	Dephosphorylation (Smad)	3.96 × 10−1−3.96 × 101 min−1 (1.3d-2)	(Chung et al. 2009)
R 10	Total number of TGF-β receptors	104/cell (1.0d1 nM)	(Hendriks et al. 2005)
R 20	Total number of EGF receptors	104/cell (1.0d1 nM)	(Hendriks et al. 2005)
S 0	Total amount of Smad	40 nM	Estimated
A 0	Total amount of EGFAM	40 nM	Estimated