Table 3.
Results of the maximal incremental test.
| MIT TEST | WT | VAChT-KDHOM | Statistics |
|---|---|---|---|
| Body weight (g) | 28.6 ± 2.7 | 24.25 ± 2.6* | p = 0.03 |
| Distance (m) | 417.3 ± 132.6 | 105.4 ± 37.6* | p = 0.0004 |
| Vmax (cm/s) | 31.2 ± 4.02 | 15.5 ± 2.2* | p < 0.0001 |
| Duration (min) | 26.8 ± 4.4 | 10.6 ± 2.4* | p < 0.0001 |
| V02 Basal (ml.Kg-l.min-1) | 15.1 ± 6.1 | 13.4 ± 4.3 | NS |
| V02 Max (ml.Kg-l.min-1) | 29.9 ± 5.4 | 25.8 ± 4.2 | NS |
| Work (J) | 21.1 ± 7.5 | 3.3 ± 0.7* | p = 0.0003 |
Statistical analysis was deployed to compare differences between 5 WT and 6 VAChT-KDHOM mice. The average whole muscle area and variability was compared between genotypes. Values represent Mean ± SEM.
*
Statistically different from WT mice based on Unpaired Student’s t-test. NS: Not Significant.