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. 2019 Mar 14;14:565–570. doi: 10.2147/CIA.S190984

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© 2019 Ding et al. This work is published and licensed by Dove Medical Press Limited

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The potential protective mechanisms of NBO on CCCI.

Notes: CCCI can induce lacunar infarction, demyelination and watershed infarction. After the use of NBO, these lesions may be improved significantly. Although the protective mechanisms presented in the figure are derived from NBO in acute stroke, the penumbra in this setting is similar to the alarming condition in CCCI. Given that, we assume that CCCI patients may benefit from NBO intervention as well.

Abbreviations: BBB, blood–brain barrier; CCCI, chronic cerebral circulation insufficiency; NBO, normobaric oxygen.