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. 2019 Mar 14;15:685–700. doi: 10.2147/NDT.S200264

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© 2019 Ma et al. This work is published and licensed by Dove Medical Press Limited

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CUMS leads the mice to express depression-like behaviors. Mice were subjected to the adaptation for a week, the CUMS for 4 weeks. (A) The values of immobile time in the FST were 170.68±1.28 seconds in CUMS-treated mice (n=12) and 141.60±1.8 seconds in controls (P<0.01). (B) The values of immobile time in the TST were 158.18±1.79 seconds in CUMS-treated mice and 124.94±0.86 seconds in controls (P<0.001). (C) The SPT values were 57.22%±1.9% in CUMS-treated mice (n=12) and 84.23%±0.92% in control mice (P<0.001). (D) The latency to eat food is 560.55±12.25 seconds in CUMS-treated mice and 344.58±7.22 in controls (P<0.001). The results are expressed as mean ± SEM. n=12 per group, ***P<0.001 compared with control.

Abbreviations: CUMS, chronic unpredictable mild stress; FST, forced swimming test; TST, tail suspension test; SPT, sucrose preference test; NST, novelty-suppressed feeding test; SEM, standard error of the mean.