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. 2019 Mar 15;12:2035–2046. doi: 10.2147/OTT.S188449

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© 2019 Cheng et al. This work is published and licensed by Dove Medical Press Limited

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Knockdown of cellular senescence-inhibited gene (CSIG) suppressed SMMC7721 cell proliferation in vitro and in vivo, CSIG overexpression could promote SMMC7721 cell migration.

Notes: (A) Western blotting showed the protein levels of CSIG in SMMC7721-shCSIG (miR30 vector-shCSIG) and SMMC7721-scramble stable cell lines. (B, C) Viability and colony formation assays were performed in SMMC7721-scramble and SMMC7721-shCSIG cells. (D) SMMC7721-shCSIG and SMMC7721-scramble cells were subcutaneously injected into nude mice on left and right side, respectively. Approximately 6 weeks after injection, tumors were photographed and weighed. (E) The migratory capabilities of SMMC7721 cells were markedly increased with PIRES-flag-CSIG plasmids transfection. ^*P<0.05, ^**P<0.01, ^***P<0.001.