Figure 2.

(A–C) Tissue levels of the NAEs in pre- and post-menopausal myometrium and fibroids. Lipids extracted from normal myometrium (Myo), tissue adjacent (adj) to the fibroid and the fibroid (Fib) itself were measured by UHPLC-MS/MS as described in the Materials and Methods section and corrected for the amount of starting material. The numbers of patient samples analyzed were: n=9 for normal pre-menopausal myometrium and n=10 for normal post-menopausal myometrium; n=7 for pre-menopausal fibroids and their adjacent myometrium; n=11 for the post-menopausal fibroid and adjacent myometrium. The data are presented as mean ± standard deviation; * P<0.05 Student’s unpaired t-test compared to normal myometrium; n.s. – not significantly different.