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. 2019 Mar 15;68(10):243–246. doi: 10.15585/mmwr.mm6810a3

FIGURE.

The figure is a flow chart representing percentages of spotted fever rickettsiosis (SFR) reports provided to CDC that met the Council of State and Territorial Epidemiologists surveillance case definition for either confirmed or probable SFR disease, along with summarized laboratory methods used to support diagnosis and case classification.

Summary of laboratory methods used to classify confirmed and probable cases of spotted fever rickettsiosis (SFR) — United States, 2010–2015 *,†,§

Abbreviations: EIA/ELISA = enzyme immunoassay/enzyme-linked immunosorbent assay; IFA = immunofluorescence assay; IgG = immunoglobulin G; IgM = immunoglobulin M; IHC = immunohistochemistry; PCR = polymerase chain reaction.

* “Confirmed SFR” and “Probable SFR” classifications are mutually exclusive; cases cannot be included in both categories.

† Percentages for “Seroconversion demonstrated by IFA in paired IgG titers” and “PCR, IHC, or culture positive” might not sum to 100% because categories are not mutually exclusive. Percentages for “IFA IgG positive” and “Other supportive laboratory evidence” also might not sum to 100% because categories are not mutually exclusive.

§ One case was reported confirmed by both “PCR” and “Seroconversion demonstrated by IFA in paired IgG titers.”