Table 2.
Unadjusted Analysis of mtDNA Copy Number Per Cell in Peripheral Blood Lymphocytes at Entry in Subjects With and Without HFE Gene Variants
| No variant HFE alleles | ≥1 variant HFE allele(s) | ||||
|---|---|---|---|---|---|
| Variable | N | Median (IQR) | N | Median (IQR) | p-value |
| All participants | |||||
| MtDNA copy number at BL | 61 | 396 (274, 537) | 24 | 668 (324, 954) | .01 |
| Change in mtDNA copy number, BL to 48 weeks (% change)a | 53 | −108 (−187, 53) | 20 | −314 (−662, −3) | .08 |
| −19% | −47% | ||||
| Whites | |||||
| MtDNA copy number at BL | 30 | 344 (231, 447) | 21 | 613 (335, 897) | .03 |
| Change in mtDNA copy number, BL to 48 weeks (% change) | 20 | −116 (−211, 70) | 16 | −314 (−662, 3) | .15 |
| −25% | −47% | ||||
p-values <.05 are considered statistically significant.
a
Longitudinal mtDNA copy number data were available in 86% of participants.
HFE, hemochromatosis gene; mtDNA, mitochondrial DNA; IQR, interquartile range; BL, baseline.