Table 2.
Differentially Regulated Gene Ontologies in Lung Adenocarcinoma Patients
| Annotation | Total genes with annotation | ln(Bayes factor) |
|---|---|---|
| GO:0007186: G-protein coupled receptor protein signaling pathway | 116 | 52.22 |
| GO:0050877: neurophysiological process | 90 | 45.06 |
| GO:0007600: sensory perception | 59 | 33.18 |
| GO:0009581: detection of external stimulus | 70 | 27.69 |
| GO:0006955: immune response | 271 | 22.42 |
| GO:0050875: cellular physiological process | 2391 | 22.28 |
| GO:0006952: defense response | 289 | 17.6 |
| GO:0009607: response to biotic stimulus | 323 | 17.37 |
| GO:0044249: cellular biosynthesis | 317 | 16.41 |
| GO:0009058: biosynthesis | 326 | 14.67 |
| GO:0050794: regulation of cellular process | 268 | 13.74 |
| GO:0006412: protein biosynthesis | 187 | 11.01 |
| GO:0009059: macromolecule biosynthesis | 204 | 10.46 |
| GO:0007166: cell surface receptor-linked signal transduction | 272 | 9.62 |
| GO:0051244: regulation of cellular physiological process | 191 | 7.79 |
| GO:0007155: cell adhesion | 195 | 7.66 |
| GO:0019882: antigen presentation | 27 | 7.05 |
| GO:0019226: transmission of nerve impulse | 32 | 6.83 |
| GO:0007268: synaptic transmission | 31 | 6.58 |
| GO:0007242: intracellular signaling cascade | 306 | 6.56 |
| GO:0006959: humoral immune response | 67 | 5.78 |
| GO:0006915: apoptosis | 150 | 5.67 |
| GO:0012501: programmed cell death | 150 | 5.4 |
| GO:0044260: cellular macromolecule metabolism | 824 | 5.28 |
GATHER analysis was performed on an mRNA expression data set from patients with lung adenocarcinomas (12) (230 samples). Enrichment of gene ontologies was identified through the Bayes factor. Differential expression of immune response-related gene ontologies was consistently and significantly preserved in the human tumors. Immune response related gene ontologies are shown in bold.
mRNA, messenger RNA.