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. Author manuscript; available in PMC: 2019 Mar 18.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 May 25;331:85–93. doi: 10.1016/j.taap.2017.05.028

Fig. 3.

Fig. 3.

Time and Dose Affect Cellular Viability. (A) At 4 h, RAW264.7 cells exposed to SITO, but not UITO, exhibited a significant decrease in cell viability as concentration was increased. (B) At 24 h in RAW264.7 cells, a 250 μg/ml concentration of either UITO or SITO significantly decreased viability when compared to 50 μg/ml. No significance was detected between UITO and SITO at matching concentrations. (C) JB6/AP-1 cells exposed to 150 μg/ml or 250 μg/ml UITO or SITO for 4 h showed significantly decreased viability compared to PBS controls. (D) In JB6/AP-1 UITO and SITO each caused concentration dependent decrease in viability at 24 h but no agent-dependent differences were observed at matching concentrations. Exposed vs. PBS: aP < 0.05; Exposed vs. Cr (VI): bP < 0.05; Compared to 50 μg/ml within exposure group: cP < 0.05.