Table 4.
Multivariable adjusted hazard ratios(HR) and associated 95% confidence intervals (95% CI) of medical conditionsa among 2-year adolescent and young adult Hodgkin lymphoma survivors (n=5,085), California, 1996–2012
| Medical conditions |
|||||||
|---|---|---|---|---|---|---|---|
| Characteristics | Circulatory system diseasesb HR (95% CI) |
Respiratory system diseasesb HR (95% CI) |
Chronic kidney disease/ renal failureb HR (95% CI) |
Liver diseasec HR (95% CI) |
Endocrine and related diseasesb HR (95% CI) |
Hypothyroidismb HR (95% CI) |
Subsequent cancersc HR (95% CI) |
| Race/ethnicityd | |||||||
| NH White | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| NH Black | 1.58 ( 1.17, 2.14) | 1.12 ( 0.82, 1.52) | 1.31 ( 0.80, 2.15) | 0.56 ( 0.24, 1.32) | 1.37 ( 1.05, 1.78) | 0.82 ( 0.49, 1.38) | 0.58 ( 0.27, 1.27) |
| Hispanic | 1.01 ( 0.82, 1.25) | 1.08 ( 0.89, 1.31) | 0.84 ( 0.59, 1.21) | 1.22 ( 0.82, 1.81) | 1.24 ( 1.04, 1.48) | 1.05 ( 0.79, 1.39) | 0.88 ( 0.60, 1.29) |
| NH Asian/Pacific Islander | 1.33 ( 0.98, 1.80) | 1.05 ( 0.76, 1.45) | 0.94 ( 0.51, 1.71) | 1.06 ( 0.54, 2.05) | 1.29 ( 0.98, 1.69) | 1.16 ( 0.76, 1.76) | 1.05 ( 0.59, 1.84) |
| Health insurance | |||||||
| Private/military | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Public/none | 1.41 ( 1.16, 1.73) | 1.57 ( 1.30, 1.89) | 1.76 ( 1.27, 2.46) | 1.52 ( 1.03, 2.24) | 1.51 ( 1.28, 1.79) | 1.29 ( 0.98, 1.72) | 0.89 ( 0.59, 1.35) |
| Unknown | 0.78 ( 0.53, 1.16) | 0.94 ( 0.68, 1.31) | 1.26 ( 0.69, 2.30) | 0.94 ( 0.44, 2.03) | 1.02 ( 0.75, 1.38) | 1.24 ( 0.88, 1.74) | 0.91 ( 0.53, 1.56) |
| Neighborhood socioeconomic status (SES) | |||||||
| Low SES | 1.10 ( 0.91, 1.33) | 1.28 ( 1.07, 1.53) | 1.30 ( 0.93, 1.81) | 1.09 ( 0.76, 1.55) | 1.30 ( 1.10, 1.53) | 0.94 ( 0.74, 1.19) | 0.92 ( 0.67, 1.27) |
| High SES | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Stem cell transplant | |||||||
| Yes | 2.04 ( 1.65, 2.52) | 3.39 ( 2.82, 4.08) | 3.31 ( 2.42, 4.54) | 2.93 ( 2.01, 4.27) | 2.58 ( 2.16, 3.07) | 1.70 ( 1.26, 2.31) | 2.07 ( 1.43, 3.02) |
| No | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Year of diagnosis | |||||||
| 1996–2000 | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| 2001–2004 | 0.97 ( 0.78, 1.21) | 0.82 ( 0.67, 1.01) | 1.10 ( 0.75, 1.62) | 1.01 ( 0.66, 1.55) | 1.00 ( 0.82, 1.20) | 1.05 ( 0.81, 1.36) | 0.86 ( 0.57, 1.29) |
| 2005–2008 | 0.79 ( 0.62, 1.01) | 0.73 ( 0.58, 0.91) | 1.45 ( 0.98, 2.15) | 0.91 ( 0.55, 1.53) | 1.02 ( 0.84, 1.25) | 0.61 ( 0.43, 0.87) | 0.90 ( 0.56, 1.47) |
| 2009–2012 | 0.86 ( 0.61, 1.21) | 0.70 ( 0.51, 0.94) | 0.94 ( 0.51, 1.73) | 1.39 ( 0.73, 2.65) | 0.84 ( 0.63, 1.12) | 0.58 ( 0.32, 1.03) | 0.51 ( 0.20, 1.31) |
NH=Non-Hispanic
a
Medical conditions obtained from hospital discharge records
b
Stratified by stage at diagnosis, initial treatment and B-symptoms; adjusted for all variables in the table and sex and age at diagnosis
c
Stratified by stage at diagnosis and initial treatment; adjusted for all variables in the table and sex, age at diagnosis, and B symptoms
d
Data for patients with other/unknown race/ethnicity not presented