TABLE 3.
Histopathologic Grading of RIBI in Animals Receiving fWBI
| F1 | F2 | F3 | F4 | F5 | |
|---|---|---|---|---|---|
| White matter necrosis | |||||
| Forebrain: white matter | + | ++++ | ++ | +++ | +++ |
| Forebrain: cortical gray matter | − | +++ | + | + | ++ |
| Prefrontal cortex | − | − | − | + | ++ |
| Basal ganglia/striatum | − | +++ | − | − | − |
| Hippocampus | − | − | − | − | − |
| Thalamus | − | ++ | − | ++ | ++ |
| Midbrain | − | ++ | − | + | +++ |
| Cerebellum | − | + | − | ++ | ++ |
| Brainstem | − | ++ | − | + | − |
| Spinal cord | − | ++ | na | + | − |
| Vascular | |||||
| Forebrain: white matter | a, c | a, b, d | − | a, b, d | b, d |
| Forebrain: cortical gray matter | − | a, d | d | a, d | b |
| Prefrontal cortex | − | − | − | − | − |
| Basal ganglia/striatum | − | − | a | − | − |
| Hippocampus | c | − | − | − | − |
| Thalamus | − | − | − | − | − |
| Midbrain | − | a, d | − | − | b |
| Cerebellum | − | − | − | − | b |
| Brainstem | − | a, d | − | − | − |
| Spinal cord | − | − | − | − | − |
Notes.
a
= Endothelial hypertrophy.
b
= Perivascular extracellular matrix deposition.
c
= Perivascular edema.
d
= Disorganized vascular morphology.