TABLE 4.

Functional Grouping of Canonical Pathways

Inflammation	ECM	Neurotransmission and signal transduction
Neuroinflammation	CDC42 signaling	Calcium signaling
Granulocyte adhesion and diapedesis	Atherosclerosis signaling	ALS signaling
Hepatic fibrosis/hepatic stellate cell activation	Hepatic fibrosis/hepatic stellate cell activation	Glutamate receptor signaling
Complement system
TREM1 signaling
Antigen presentation pathway
Th1 and Th2 activation pathway
Type 1 diabetes mellitus signaling
Allograft rejection signaling
OX40 signaling
Th1 pathway
Th2 pathway
B-cell development
Dendritic cell maturation
Autoimmune thyroid disease signaling
T-helper cell differentiation
Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza