TABLE 5.

Molecular Function Analysis of Neuroinflammatory Genes in Irradiated Brain

	Fold enrichment	P value
fWBI, dorsolateral prefrontal cortex
aMHC class II receptor activity	>100.00	1.50E–04
Platelet-derived growth factor binding	>100.00	1.50E–04
aMHC class II protein complex binding	>100.00	2.66E–04
aPeptide antigen binding	>100.00	5.29E–05
Integrin binding	34.91	3.63E–02
fWBI, hippocampus
aMHC class II receptor activity	>100.00	1.26E–05
aPeptide antigen binding	>100.00	1.03E–06
aMHC class II protein complex binding	>100.00	1.11E–02
fWBI, white matter
bOpsonin receptor activity	89.16	1.20E–03
Tumor necrosis factor binding	79.25	2.78E–02
ICAM-3 receptor activity	79.25	2.75E–02
Glutamate-gated calcium ion channel activity	71.33	1.76E–03
NMDA glutamate receptor activity	67.93	1.42E–04
Calcium-dependent protein kinase C activity	59.44	3.81E–02
bComplement component C3b binding	59.44	3.78E–02
Benzodiazepine receptor activity	59.44	2.39E–03
Lipoteichoic acid binding	59.44	3.75E–02
CCR2 chemokine receptor binding	59.44	3.72E–02
TBI, white matter
aMHC class II receptor activity	>100.00	2.78E–02
Platelet-derived growth factor receptor binding	>100.00	4.06E–02
CXCR chemokine receptor binding	>100.00	4.13E–02
Chemokine activity	53.68	1.06E–02
Cytokine binding	34.38	5.49E–03
Cytokine receptor activity	28.28	3.99E–02
bSerine-type endopeptidase activity	16.99	7.86E–03
aPeptide binding	13.13	4.87E–02

Notes. Analyses completed in Gene Ontology enrichment analysis tool. Maximum fold-enrichment values are truncated at 100. The top 10 enriched ontologies are reported in order of decreasing fold-enrichment and statistical significance, multiplicity adjusted P values ≤ 0.05 were considered significant. Overarching molecular function:

^aMHC class II peptide antigen presentation

^bcomplement activation.