. Author manuscript; available in PMC: 2020 Mar 1.

Published in final edited form as: Radiat Res. 2019 Jan 29;191(3):217–231. doi: 10.1667/RR15263.1

TABLE 6.

Molecular Function Analysis of Extracellular Matrix and Remodeling-Associated Genes in fWBI Brain

	Fold enrichment	P value
fWBI, dorsolateral prefrontal cortex
^aPlatelet-derived growth factor binding	>100.00	2.96E–04
fWBI, white matter
Tumor necrosis factor binding	>100.00	5.93E–03
^aPlatelet-derived growth factor binding	>100.00	6.18E–06
Interleukin-1 receptor activity	>100.00	1.80E–02
Tumor necrosis factor-activated receptor activity	99.63	1.50E–06
^aPlatelet-derived growth factor receptor binding	95.65	1.16E–03
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity	43.48	2.51E–06
^bExtracellular matrix structural constituent	42.92	5.27E–07
^bIntegrin binding	29.62	1.85E–06
^bProtease binding	24.98	3.89E–06
^bCollagen binding	22.77	3.80E–02

Notes. Analyses completed in Gene Ontology enrichment analysis tool. Maximum fold-enrichment values are truncated at 100. The top 10 enriched ontologies are reported in order of decreasing fold-enrichment and statistical significance, multiplicity adjusted P values ≤ 0.05 were considered significant. Overarching molecular function:

Platelet derived growth factor (PDGF) signaling

ECM remodeling.