TABLE 7.

Molecular Function Analysis of Neurotransmission and Signal Transduction Associated Genes in White Matter

	Fold enrichment	P value
fWBI, white matter
aNeurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	>100.00	2.64E–03
bGlutamate-gated calcium ion channel activity	>100.00	4.11E–05
bNMDA glutamate receptor activity	>100.00	2.13E–06
bAdenylate cyclase inhibiting G-protein coupled glutamate receptor activity	>100.00	4.97E–03
bGlutamate binding	>100.00	2.05E–04
bExtracellularly glutamate-gated ion channel activity	>100.00	7.71E–07
bHigh voltage-gated calcium channel activity	>100.00	2.34E–04
Glycine binding	>100.00	3.94E–04
bL-glutamate transmembrane transporter activity	88.41	2.30E–02
aCalcium channel regulator activity	53.05	3.19E–03
TBI, white matter
bIonotropic glutamate receptor activity	>100.00	6.99E–03
bExtracellularly glutamate-gated ion channel activity	>100.00	6.75E–03
aLigand-gated calcium channel activity	>100.00	1.01E–02
Actinin binding	97.87	2.87E–02
Neurotransmitter binding	80.93	4.01E–02

Notes. Analyses completed in Gene Ontology enrichment analysis tool. Maximum fold-enrichment values are truncated at 100. The top 10 enriched ontologies are reported in order of decreasing fold-enrichment and statistical significance, multiplicity adjusted P values ≤ 0.05 were considered significant. Overarching molecular function:

^aCalcium ion regulation

^bglutamatergic neurotransmission.