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. Author manuscript; available in PMC: 2019 Mar 18.
Published in final edited form as: Methods Mol Biol. 2016;1341:391–406. doi: 10.1007/7651_2015_215

Figure 3: Cell aggregate morphology during inner ear organoid culture.

Figure 3:

DIC images captured from R1 ESC otic differentiation cultures highlighting the morphological progression. a-f, Early morphology from day 1 to day 10. g-h, Later morphology; day 14 aggregate, arrow head indicating vesicle formation. i, Day 18 vesicle; site of inner ear sensory epithelia formation. Scale bars, 100 μm.