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. Author manuscript; available in PMC: 2019 Jun 20.
Published in final edited form as: Annu Rev Biochem. 2018 Apr 13;87:697–724. doi: 10.1146/annurev-biochem-062917-011931

Table 1.

Proteasome subunit names and function

Subcomplex Saccharomyces cerevisiae Homo sapiens Function
Base Rpn1 PSMD2/S2 Ubp6 and ubiquitin/UBL binding
Rpn2 PSMD1/S1 Structural
Rpn13 ADRM1 Ubiquitin/UBL binding
Rpt1 PSMC2/S7 ATPase
Rpt2 PSMC1/S1 ATPase
Rpt3 PSMC4/S6 ATPase
Rpt4 PSMC6/S10 ATPase
Rpt5 PSMC3/S6a ATPase
Rpt6 PSMC5/S8 ATPase
Lid Rpn3 PSMD3/S3 Structural
Rpn5 PSMD12 Structural
Rpn6 PSMD11/S9 Structural
Rpn7 PSMD6/S10 Structural
Rpn8 PSMD7/S12 Structural
Rpn9 PSMD13/S11 Structural
Rpn11 PSMD14/Poh1/Pad1 Deubiquitinase
Rpn12 PSMD8/S14 Structural
Sem1 PSMD9/Dss1/Rpn15 Structural
Additional cofactor Rpn10 PSMD4/S5a Ubiquitin/UBL binding
Associated deubiquitinases Ubp6 Usp14 Deubiquitinase
NA Uch37 Deubiquitinase

Abbreviations: NA, not available; UBL, ubiquitin-like.