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. Author manuscript; available in PMC: 2019 Jun 20.
Published in final edited form as: Annu Rev Biochem. 2018 Apr 13;87:697–724. doi: 10.1146/annurev-biochem-062917-011931

Table 2.

Proteasome conformations and prominent features of each conformation

Proteasome conformation Prominent features of conformation
Saccharomyces cerevisiae Homo sapiens Rpn11 position Relative position of N-ring, AAA+ ring, and 20S core 20S core particle gate AAA+ domain configuration
s1 (27, 28, 48, 50) SA (44, 50–52) Offset from central processing pore Not aligned Full density, closed Steep spiral staircase,
Rpt3 at the top
s2 (39) SB (44, 51) Aligned with central processing pore Not aligned Full density, closed Steep spiral staircase,
Rpt3 at the top
s3 (37, 38, 41) SC (44) Aligned with central processing pore Aligned Full density, closed Shallow spiral staircase,
Rpt1 at the top
s4 (40) SD(1, 2, 3) (44, 45) Aligned with central processing pore Aligned Partial density, open Shallow spiral staircase,
Rpt5 at the top