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. 2019 Jan 11;294(11):4160–4168. doi: 10.1074/jbc.RA118.003837

Figure 1.

Figure 1.

Atrogin-1 regulates SK2 protein expression in HL-1 cells. A, adenovirus-mediated overexpression of atrogin-1 in HL-1 cells was associated with a significant reduction in SK2 protein levels (*, p < 0.05; n = 3) but had no effect on those of SK1 and SK3 (p = N.S., n = 3). B, knockdown of atrogin-1 using atrogin-1 siRNAs achieved a 71% reduction in atrogin-1 protein expression in HL-1 cells, and this was accompanied by a significant 2.1-fold up-regulation of SK2 protein (*, p < 0.05; n = 3). Atrogin-1 knockdown had no significant effect on the levels of SK1 and SK3 protein expression (p = N.S., n = 3).