Figure 2.

Applications of HDX–MS to study lipid-signaling systems. Shown is a schematic of the cell with different lipid-signaling systems studied by HDX–MS highlighted. The different studies, which focus on the use of HDX–MS to study protein–protein, protein–ligand, and protein–membrane interactions, as well as looking at how disease-linked mutations cause allosteric activating conformational changes. Full details on these specific studies can be found in the References.