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Retinoblastoma managed with intra-arterial chemotherapy (IAC) plus intravitreal chemotherapy. a Group D retinoblastoma in a 24-month-old female demonstrated tumor regression (b) following one cycle of IAC with melphalan and 6 intravitreal melphalan injections. c Group D retinoblastoma in a 20-month-old male showed tumor regression (d) following four cycles of IAC with melphalan and topotecan plus 6 intravitreal melphalan injections.
