Skip to main content
. 2018 Aug 21;5(2):139–146. doi: 10.1159/000491580

Table 2.

Clinical features at diagnosis

Primary IAC alone (n = 34) Primary IAC with IvitC (n = 20) p values Total patients (n = 54)
ICRB classification
 Group B 2 (6) 0 (0) 0.42 2 (4)
 Group C 3 (9) 0 (0) 3 (6)
 Group D 17 (50) 13 (65) 30 (56)
 Group E 12 (35) 7 (35) 19 (35)
Mean number of tumors per eye 1 (1, 1–1) 1 (1, 1–2) 0.10 1 (1, 1–2)
Mean largest diameter, mm 18 (20, 10–24) 18 (18, 13–24) 0.96 18 (18, 10–24)
Mean thickness, mm 10 (10, 4–18) 9 (10, 4–14) 0.49 10 (10, 4–18)
Mean distance to optic nerve, mm 1 (0, 0–10) 2 (1, 0–10) 0.02 1 (0, 0–10)
Mean distance to foveola, mm 1 (0, 0–12) 3 (3, 0–7) 0.02 1 (0, 0–12)

Vitreous seeds
 None 23 (68) 2 (10) <0.01 25 (46)
 1 quadrant 2 (6) 3 (15) 5 (9)
 2 quadrants 4 (12) 3 (15) 7 (13)
 3 quadrants 1 (3) 2 (10) 3 (6)
 4 quadrants 4 (12) 10 (50) 14 (26)
Subretinal seeds
 None 13 (38) 7 (35) 0.50 20 (37)
 1 quadrant 6 (18) 3 (15) 9 (17)
 2 quadrants 6 (18) 1 (5) 7 (13)
 3 quadrants 3 (9) 2 (10) 5 (9)
 4 quadrants 5 (15) 4 (20) 9 (17)
 no view 1 (3) 3 (15) 4 (7)

Retinal detachment
 None 2 (6) 7 (35) 0.07 9 (17)
 ≤1 quadrant 4 (12) 2 (10) 6 (11)
 2 quadrants 6 (18) 1 (5) 7 (13)
 3 quadrants 3 (9) 1 (5) 4 (7)
 4 quadrants 18 (53) 7 (35) 25 (46)
 no view 1 (3) 2 (10) 3 (6)
Vitreous hemorrhage 1 (3) 1 (5) 0.99 2 (4)
Anterior segment findings
 Anterior chamber seeds 0 (0) 1 (5) 0.37 1 (2)
 Iris neovascularization 1 (3) 0 (0) 0.63 1 (2)
 Neovascular glaucoma 0 (0) 0 (0) 0.99 0 (0)
Visual acuity
 ≥20/200 13 (38) 11 (55) 0.27 24 (44)
 <20/200 21 (62) 9 (45) 30 (56)

Figures in parentheses indicate percentages or median and range. Bold values indicate significant p values. IAC, intra-arterial chemotherapy; IvitC, intravitreal chemotherapy; ICRB, International Classification of Retinoblastoma.