Table 2.
Clinical features at diagnosis
| Primary IAC alone (n = 34) | Primary IAC with IvitC (n = 20) | p values | Total patients (n = 54) | |
|---|---|---|---|---|
| ICRB classification | ||||
| Group B | 2 (6) | 0 (0) | 0.42 | 2 (4) |
| Group C | 3 (9) | 0 (0) | 3 (6) | |
| Group D | 17 (50) | 13 (65) | 30 (56) | |
| Group E | 12 (35) | 7 (35) | 19 (35) | |
| Mean number of tumors per eye | 1 (1, 1–1) | 1 (1, 1–2) | 0.10 | 1 (1, 1–2) |
| Mean largest diameter, mm | 18 (20, 10–24) | 18 (18, 13–24) | 0.96 | 18 (18, 10–24) |
| Mean thickness, mm | 10 (10, 4–18) | 9 (10, 4–14) | 0.49 | 10 (10, 4–18) |
| Mean distance to optic nerve, mm | 1 (0, 0–10) | 2 (1, 0–10) | 0.02 | 1 (0, 0–10) |
| Mean distance to foveola, mm | 1 (0, 0–12) | 3 (3, 0–7) | 0.02 | 1 (0, 0–12) |
| Vitreous seeds | ||||
| None | 23 (68) | 2 (10) | <0.01 | 25 (46) |
| 1 quadrant | 2 (6) | 3 (15) | 5 (9) | |
| 2 quadrants | 4 (12) | 3 (15) | 7 (13) | |
| 3 quadrants | 1 (3) | 2 (10) | 3 (6) | |
| 4 quadrants | 4 (12) | 10 (50) | 14 (26) | |
| Subretinal seeds | ||||
| None | 13 (38) | 7 (35) | 0.50 | 20 (37) |
| 1 quadrant | 6 (18) | 3 (15) | 9 (17) | |
| 2 quadrants | 6 (18) | 1 (5) | 7 (13) | |
| 3 quadrants | 3 (9) | 2 (10) | 5 (9) | |
| 4 quadrants | 5 (15) | 4 (20) | 9 (17) | |
| no view | 1 (3) | 3 (15) | 4 (7) | |
| Retinal detachment | ||||
| None | 2 (6) | 7 (35) | 0.07 | 9 (17) |
| ≤1 quadrant | 4 (12) | 2 (10) | 6 (11) | |
| 2 quadrants | 6 (18) | 1 (5) | 7 (13) | |
| 3 quadrants | 3 (9) | 1 (5) | 4 (7) | |
| 4 quadrants | 18 (53) | 7 (35) | 25 (46) | |
| no view | 1 (3) | 2 (10) | 3 (6) | |
| Vitreous hemorrhage | 1 (3) | 1 (5) | 0.99 | 2 (4) |
| Anterior segment findings | ||||
| Anterior chamber seeds | 0 (0) | 1 (5) | 0.37 | 1 (2) |
| Iris neovascularization | 1 (3) | 0 (0) | 0.63 | 1 (2) |
| Neovascular glaucoma | 0 (0) | 0 (0) | 0.99 | 0 (0) |
| Visual acuity | ||||
| ≥20/200 | 13 (38) | 11 (55) | 0.27 | 24 (44) |
| <20/200 | 21 (62) | 9 (45) | 30 (56) | |
Figures in parentheses indicate percentages or median and range. Bold values indicate significant p values. IAC, intra-arterial chemotherapy; IvitC, intravitreal chemotherapy; ICRB, International Classification of Retinoblastoma.