Figure 3. Murine skin DC subsets drive distinct T cell phenotypes.

LC, dermal cDC1, and dermal cDC2 promote distinct but overlapping T cell phenotypes. In most contexts, the same antigen is present in both the epidermis and dermis resulting in a redundancy between LC and dermal DC subsets. A requirement for LC is observed primarily when antigens or adjuvants are confined to the epidermis. Strong evidence is shown by red arrows and suggestive evidence is shown in blue.