Table 3.
Functional annotation of significantly modulated protein expression in the IC following H2S exposure at 2h, days 2, and 4. Table displays dysregulated molecular pathways and total number of proteins associated with GO-term definition. Note the similarity in pathways at 2 h and on day 2.
| ID | Name | #Gene | FDR |
|---|---|---|---|
| 2h | |||
| P00041 | Metabotropic glutamate receptor group I pathway | 2 | 5.31E-01 |
| P02772 | Pyruvate metabolism | 1 | 1.00E + 00 |
| P00019 | Endothelin signaling pathway | 2 | 1.00E + 00 |
| P02746 | Heme biosynthesis | 1 | 1.00E + 00 |
| P00031 | Inflammation mediated by chemokine and cytokine signaling pathway | 3 | 1.00E + 00 |
| P06664 | Gonadotropin-releasing hormone receptor pathway | 3 | 1.00E + 00 |
| P00024 | Glycolysis | 1 | 1.00E + 00 |
| P04386 | Histamine H2 receptor mediated signaling pathway | 1 | 1.00E + 00 |
| P05913 | Enkephalin release | 1 | 1.00E + 00 |
| P00017 | DNA replication | 1 | 1.00E + 00 |
| Day 2 | |||
| P00041 | Metabotropic glutamate receptor group I pathway | 2 | 5.79E-01 |
| P00017 | DNA replication | 2 | 5.79E-01 |
| P02772 | Pyruvate metabolism | 1 | 1.00E + 00 |
| P02746 | Heme biosynthesis | 1 | 1.00E + 00 |
| P00019 | Endothelin signaling pathway | 2 | 1.00E + 00 |
| P00031 | Inflammation mediated by chemokine and cytokine signaling pathway | 3 | 1.00E + 00 |
| P06664 | Gonadotropin-releasing hormone receptor pathway | 3 | 1.00E + 00 |
| P00024 | Glycolysis | 1 | 1.00E + 00 |
| P04386 | Histamine H2 receptor mediated signaling pathway | 1 | 1.00E + 00 |
| P05913 | Enkephalin release | 1 | 1.00E + 00 |
| Day 4 | |||
| P00029 | Huntington disease | 2 | 1.00E + 00 |
| P00020 | FAS signaling pathway | 1 | 1.00E + 00 |
| P06664 | Gonadotropin-releasing hormone receptor pathway | 2 | 1.00E + 00 |
| P00016 | Cytoskeletal regulation by Rho GTPase | 1 | 1.00E + 00 |