Table 2.

Conscious transthoracic echocardiography performed on 8 week-old MuRF1−/− and strain-matched MuRF1+/+ mice.

	Baseline MuRF1+/+ n=9	Baseline MuRF1−/− n=6	MuRF1+/+ DOX 20 mg/kg 7 Days n=8	MuRF1−/− DOX 20 mg/kg 7 Days n=5
AWTD (mm)	0.97 ± 0.06	0.94 ± 0.05	0.93 ± 0.08	0.95 ± 0.07
AWTS (mm)	1.72 ± 0.12	1.74 ± 0.12	1.30 ± 0.17	1.48 ± 0.20
LVEDD	3.24 ± 0.39	3.36 ± 0.32	2.98 ± 0.59	3.05 ± 0.25
LVESD	1.53 ± 0.24	1.55 ± 0.27	1.93 ± 0.45	1.73 ± 0.22
PWTD (mm)	0.94 ± 0.09	0.98 ± 0.07	0.87 ± 0.14	0.90 ± 0.16
PWTS (mm)	1.57 ± 0.15	1.67 ± 0.17	1.25 ± 0.22*	1.44 ± 0.22
EF (%)	84.8 ± 3.0	85.8 ± 3.4	66.5 ± 5.4†	76.1 ± 4.5*
FS (%)	52.8 ± 3.0	54.2 ± 3.9	35.5 ± 4.0†	43.6 ± 4.0‡
LV Vol;d (ml)	42.9 ± 11.7	46.5 ± 11.3	36.3 ± 18.3*	36.9 ± 6.9
LV Vol;s (ml)	6.69 ± 2.88	6.87 ± 3.41	12.66 ± 8.29	8.94 ± 2.68
Body Weight (g)	22.6 ± 2.7	24.6 ± 2.0	19.4 ± 2.5†	23.1 ± 2.7

Data represent means ± SD. A One-Way Analysis of Variance was performed, followed by an all pairwise multiple comparison procedure (Holm- Sidak method), * vs. Column 1 and Column 2, † vs. All other columns, ‡ vs. Column 1.

AWTD, anterior wall thickness in diastole; AWTS, anterior wall thickness in systole; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; PWTD, posterior wall thickness in diastole; PWTS, posterior wall thickness in systole; FS, fractional shortening, calculated as (LVEDD-LVESD)/LVEDD x 100; EF%, Ejection Fraction calculated as (end Simpson’s diastolic volume – end Simpson’s systolic volume)/end Simpson’s diastolic volume * 100.