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. Author manuscript; available in PMC: 2019 Oct 22.
Published in final edited form as: Biochem J. 2018 Oct 22;475(20):3221–3238. doi: 10.1042/BCJ20180424

Figure 1. Reactions catalyzed by WT and mutant IDH1.

Figure 1.

(A) WT IDH1 catalyzes the reversible, NADP+-dependent oxidation of ICT to αKG (OS, oxalosuccinate). (B) Mutant IDH1 is typically deficient in the normal reaction shown in (A) and instead acquires a neomorphic reaction, the NADPH-dependent reduction in αKG to generate the oncometabolite, D2HG [10]. For both reactions, the predicted catalytic cycle is also shown.