. Author manuscript; available in PMC: 2019 Oct 22.

Published in final edited form as: Biochem J. 2018 Oct 22;475(20):3221–3238. doi: 10.1042/BCJ20180424

Table 3. Biochemical IC₅₀ measurements for the pan-inhibitor GSK864.

Percent activity of an incubation of IDH1, NADPH, and αKG with increasing concentrations of inhibitor were determined and plotted against log[inhibitor] and fit to a sigmoidal function. The 95% confidence intervals are shown as determined from the deviation from these fits.

IDH1	GSK864 IC₅₀ (μM) [confidence interval]
WT	0.24 [0.15–0.40]
R132H	0.005 [0.004–0.008]
R132Q	0.17 [0.11–0.25]

Table 3. Biochemical IC50 measurements for the pan-inhibitor GSK864.

Table 3. Biochemical IC₅₀ measurements for the pan-inhibitor GSK864.