Table 1. Comparison of the differences in ASL-related biomarkers between HGGs and LGGs and between different glioma grades.
| Biomarkers | Number of studies | Total sample size | Heterogeneity | Effect size | Egger test to evaluate publication bias | |||
|---|---|---|---|---|---|---|---|---|
| LGG | HGG | P-value | I2 | SMD (95% CI) (*) | P-value | P-value | ||
| rTBF | 15 | 237 | 323 | <0.001 | 86% | –1.46 (–2.00, –0.91) | <0.001 | 0.17 |
| rTBF mean | 9 | 142 | 192 | <0.001 | 86% | –1.53 (–2.26, –0.79) | <0.001 | 0.72 |
| rTBF max | 6 | 95 | 131 | <0.001 | 87% | –1.36 (–2.23, –0.49) | 0.002 | 0.24 |
| TBF | 11 | 155 | 219 | 0.002 | 64% | –0.82 (–1.20, –0.45) | <0.001 | 0.05 |
| TBF mean | 4 | 51 | 70 | 0.50 | 0% | –0.61 (–0.99, –0.23) | 0.002 | 0.43 |
| TBF max | 7 | 104 | 149 | <0.001 | 76% | –0.96 (–1.53, –0.39) | 0.001 | 0.10 |
| II | III | |||||||
| rTBF | 4 | 62 | 48 | 0.26 | 25% | –1.39 (–1.89, –0.89) | <0.001 | 0.46 |
| TBF | 2 | 43 | 21 | 0.09 | 66% | –0.90 (–1.85, 0.04) | 0.06 | (-) |
| II | IV | |||||||
| rTBF | 4 | 62 | 61 | <0.001 | 87% | –2.07 (–3.38, –0.76) | 0.002 | 0.25 |
| TBF | 2 | 43 | 32 | 0.01 | 84% | –1.44 (–2.76, –0.12) | 0.03 | (-) |
| III | IV | |||||||
| rTBF | 6 | 54 | 69 | 0.006 | 69% | –1.05 (–1.82, –0.27) | 0.008 | 0.19 |
| TBF | 4 | 27 | 40 | 0.64 | 0% | –0.45 (–0.95, 0.05) | 0.08 | 0.04 |
(*) SMD calculated as the difference between LGGs ASL-parameters and HGGs ASL-parameters (usually higher than the LGG counterparts).
(-) No pooled results due to low number of included studies.