. 2019 Feb 22;10(16):1589–1601. doi: 10.18632/oncotarget.26674

Table 3. Diagnostic performance of the ASL imaging biomarkers in stratifying the tumours between HGGs and LGGs.

Biomarker	Number of studies	Total sample size		Sensitivity (95% CI)	Specificity (95% CI)	AUC (95% CI)
Biomarker	Number of studies	LGGs	HGGs	Sensitivity (95% CI)	Specificity (95% CI)	AUC (95% CI)
All	17	206	397	86% (78%, 91%)	84% (76%, 90%)	0.91, (0.89, 0.93)
TBF	1	(^*)	(^*)	(^*)	(^*)	(^*)
rTBF	16	181	370	86% (77%, 91%)	84% (76%, 90%)	0.91, (0.89, 0.94)
rTBF max	5	76	122	85% (69%, 94%)	92% (80%, 97%)	0.95, (0.93, 0.97)
rTBF mean	8	80	188	84% (71%, 92%)	79% (66%, 88%)	0.87, (0.84, 0.90)

(^*) No pooled results due to low number of included studies.