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. 2019 Mar 1;10(18):1716–1728. doi: 10.18632/oncotarget.26733

Figure 3. Simvastatin reduces migration and invasion and induces apoptosis and autophagy in GBM and GICs.

Figure 3

(A) Simvastatin ablated cell spreading from adherent spheroids of G34 with a single simvastatin dose applied for 6 days. (B), (C) Simvastatin reduced migration and invasion of U251MG (B) and G34 cells (C). (D) Simvastatin induced apoptosis as indicated by increasing caspase3/7 activity (left panel) and cleaved PARP expression (right panel) in U251MG and G34. (E) Simvastatin stimulated autophagy as indicated by increased LC3A/B-II expression in U251MG and G34. Sim: simvastatin. All values are the mean±SD of three experiments. *, P<0.05; **, P<0.01. ***, P<0.001. ****, P<0.0001.