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. Author manuscript; available in PMC: 2019 Mar 18.
Published in final edited form as: Future Med Chem. 2015;7(3):243–256. doi: 10.4155/fmc.14.168

Figure 1. Three important pharmacophores of TRPV1 ligands.

Figure 1

Pharmacophoric comparison of (1) capsaicin [7], (2) capsazepine [7], (3) benzylthiourea derivatives [33], (4) piperidine carboxamide derivatives [35], (5) 1,3,4-thiadiazole derivatives [36] according to three structural sections of TRPV1 ligands: (A) polar head, (B) linker and (C) hydrophobic tail.