Table 1. List of templates that were used for homology models of P-glycoprotein.

Template	Organsim	Sequence Identitiy/Similarity[a]	Co-crystal[b]	PDB Code	Resolution [Å]	Reference	Homology Models
MsbA	E. coli	36%/57%	Apo-open[c]	1JSQ	4.50	[15] Retracted	[52, 64, 65]
MsbA	V. cholerae	33%/55%	Apo-closed[d]	1PF4	3.80	[66] Retracted	[67]
MsbA	S. typhimurium	37%/57%	ADP·Vi	1Z2R	4.20	[68] Retracted
Sav1866	S. aureus	34%/52%	ADP	2HYD	3.00	[48]	[69–74]
MsbA	E. coli	36%/57%	Apo-open	3B5W	5.30	[60]	[75]
MsbA	V. cholerae	33%/55%	Apo-closed	3B5X	5.50	[60]	[72]
MsbA	S. typhimurium	37%/57%	AMP-PNP	3B5Y	4.50	[60]
MsbA	S. typhimurium	37%/57%	ADP·Vi	3B5Z	4.20	[60]
MsbA	S. typhimurium	37%/57%	AMP-PNP	3B60	3.70	[60]	[72]
MalK	E. coli	31%/50%	Apo-semi open	1Q1B	2.80	[73]	[73]
MalK	E. coli	31%/50%	Apo-open	1Q1E	2.90	[73]	[73]
ABCB1	M. musculus	87%/93%	Apo-closed	3G5U	3.80	[16]	[76, 77]
ABCB1	M. musculus	87%/93%	QZ59-RRR	3G60	4.40	[16]
ABCB1	M. musculus	87%/93%	QZ59-SSS	3G61	4.35	[16]	[78]

^[a]Sequence Identity/Similarity with human P-glycoprotein[79].

^[b]Co-crystallized molecules (Nucleotides, drugs or apo).

^[c]Apo-open describes the nucleotide-free protein with the NBDs far apart.

^[d]Apo-closed describes the nucleotide-free protein with NBDs that lie close together