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. Author manuscript; available in PMC: 2019 Mar 18.
Published in final edited form as: Adv Drug Deliv Rev. 2015 Mar 11;86:17–26. doi: 10.1016/j.addr.2015.03.001

Fig. 1.

Fig. 1

Cooperation of BSEP, ABCB4 and MRP2 in the canalicular membrane of hepatocytes. BSEP (blue) exports the bile salts, ABCB4 (green) flips phosphatidylcholine to the outer leaflet of the membrane, where it is recruited by bile salts to form mixed micelles. MRP2 (red) maintains the asymmetry in lipid composition by flipping aminophospholipids to the inner leaflet of the membrane.