Table 3.
Association between low nasal nitric oxide and postoperative outcomes*
| All Surgical Events (n=95) |
Surgical Events for patients with nNO Data (n = 83) |
|||
|---|---|---|---|---|
| Normal nNO (n=48) |
Low nNO (n=35) |
P | ||
| Postoperative LOS (days) | 15 (10–24) | 15 (10–20) | 18 (10–29) | 0.28 |
| Total CICU LOS (days) | 8 (5–11) | 7 (4–9) | 10 (5–12) | 0.041 |
| Initial CICU LOS (days) | 7 (5–11) | 7 (4–8) | 10 (5–12) | 0.042 |
| Abn PostOp Sys Fxn†, n (%) | 22 (23%) | 6 (13%) | 12 (34%) | 0.056 |
| ECMO, n (%) | 10 (11%) | 6 (13%) | 3 (9%) | 0.58 |
| Delayed sternal closure, n (%) | 58 (61%) | 28 (58%) | 23 (66%) | 0.50 |
| Mechanical ventilation, n (%) | 84 (88%) | 42 (88%) | 31 (89%) | 0.91 |
| Supportive ventilation, n (%) | 88 (93%) | 46 (96%) | 32 (91%) | 0.42 |
| NIPPV‡, n (%) | 24 (25%) | 11 (23%) | 8 (23%) | 0.92 |
| Reintubation, n (%) | 15 (16%) | 6 (13%) | 7 (20%) | 0.39 |
| Respiratory medication (any) use, n (%) | 31 (33%) | 13 (27%) | 12 (34%) | 0.50 |
| Dexmedetomidine (days) | 4 (2–7) | 3 (2–6) | 6(3–8) | 0.002 |
| Fentanyl (days) | 3 (2–5) | 3 (2–5) | 4(3–6) | 0.098 |
| Milrinone (days) | 5 (3–7) | 4 (3–6) | 6 (4–8) | 0.021 |
| Nicardipine use, n (%) | 17 (18%) | 3 (6%) | 12 (34%) | 0.034 |
| Overall infection, n (%) | 28 (30%) | 8 (17%) | 16 (46%) | 0.01 |
| Bacterial Infection, n (%) | 25 (26%) | 8 (17%) | 13 (37%) | 0.048 |
| Viral Infection, n (%) | 4 (4%) | 1 (2%) | 1 (3%) | 0.83 |
*
Data are median (IQR) or n (%). P-values were obtained from the linear mixed models and generalized linear mixed model for continuous and categorical variables, respectively.
†
Abn Postop Sys Fxn = abnormal postoperative systolic ventricular function of systemic ventricle
‡
NIPPV = Non-invasive positive pressure ventilation