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. Author manuscript; available in PMC: 2019 Oct 4.
Published in final edited form as: Curr Probl Surg. 2018 Oct 4;55(9):330–379. doi: 10.1067/j.cpsurg.2018.08.004

Table 4.

Prognostic variables for hepatic colorectal metastases.

Prognostic Variables Author
Clinical indicators
 *Node-positive primary tumor Fong et al. 1999 (13)
 *Disease-free interval less than 12 months from primary
 *Size of largest lesion >5 cm
 *More than one tumor
 *Carcinoembryonic antigen >200 ng/dl
 Extrahepatic disease Poultsides et al. 2012(55)
 Response to chemotherapy
 Fibrotic response to chemotherapy
Pathologic indicators
 Margin positive resection Turcotte et al. 2014 (56)
 High TIL Cells
Molecular indicators
 CXCR4 Yopp et al. 2014 (57)
 HumanHT-12 gene Chip/MRS panel Ito et al. 2013 (59)
 kRAS Kemeny et al. 2014 (293)

Notes:

*

components of the CRS scoring system (One point assigned for each positive criterion. Sum of points is CRS).