Figure 9.
Relation between the IFNγ response of CRC explant cultures and the density of Tbet+ or PD1+ TILs, and the expression profile of PDL1 or IDO-1. The level of IFNγ secreted in 24 h explant cultures of CRC is positively correlated with the density of Tbet+ TILs (a) and the PDL1 expression profile (c). Most of CRC devoid of an IFNγ response displayed high numbers of PD1+ TILs (b) or a high IDO-1 score in tumor cells (d). Black dots: MSS CRC. Grey dots: MSI CRC. Spearman correlation test.