Table 2.

Multivariate analysis in the whole cohort of patients (Cox regression model).

Variables	HR	CI	p-value
pTNM stage IV vs. others	4.52	1.91;10.7	0.0006
Age	1.06	1.01;1.12	0.012
MSI vs. MSS	2.13	0.9;5.04	0.08
Density of Tbet ≥40/field	0.31	0.13;0.75	0.009
Density of CD3 ≥ 591/field	0.72	0.3;1.74	0.466

HR: Hazard Ratio; CI: Confidence Interval