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. 2019 Feb 6;8(4):e1568809. doi: 10.1080/2162402X.2019.1568809

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Figure 2. — E6 and E7 expression in early and late MOC2-E6E7 tumors in immunocompetent and immunocompromised mice.

E6 (a) and E7 (b) mRNA expression were determined relative to that of ß-actin in CD45-depleted MOC2-E6E7 tumors from C57BL/6J wild type or Rag1^-/- mice. As controls, E6 and E7 expression in CD45-depleted mEER tumors were determined. E6 and E7 expression are maintained in mEER and MOC2-E6E7 tumors grown in Rag1^-/- mice while a loss of E6 and E7 expression is observed in MOC2-E6E7 tumors grown in wild type mice. ^a, p < 0.0001 vs. E6 mRNA expression in mEER 6 mm tumors, ^b, p < 0.0001 vs. E6 mRNA expression in mEER 10 mm tumors p = 0.0032; ^c, p < 0.0001 vs. E7 mRNA expression in mEER 6 mm tumors. ^d, p < 0.0001 vs. E7 mRNA expression in mEER 10 mm tumors, ^e, p = 0.0102 vs. E7 mRNA expression in mEER 10 mm tumors, ^f, p = 0.0002 vs. E7 mRNA expression in MOC2-E6E7 10 mm tumors. Error bars, as mean ± SD.