Table 2.

Clinicopathologic factors associated with OS and FFP after RT2 on univariate analysis

Variable	Overall Survival		Freedom from Progression
	HR (95% CI)	P	HR (95% CI)	P
Supratentorial (vs infratentorial)	1.1 (0.41–3.0)	0.84	0.98 (0.37–2.5)	0.98
Less than GTR before RT1 (vs GTR)	2.0 (0.65–6.2)	0.22	2.6 (0.92–7.1)	0.071
Less than GTR before RT2 (vs GTR)	1.9 (0.74–5.0)	0.18	1.7 (0.69–4.0)	0.26
Treatment group
LF/focal RT2	Reference		Reference
LF/CSI RT2	0.30 (0.04–2.4)	0.26	0.14 (0.02–1.1)	0.061
dissem/CSI RT2	2.5 (0.82–7.4)	0.11	1.5 (0.57–4.1)	0.40
Time between RT1 and RT2 (per year)	0.93 (0.77–1.1)	0.52	0.91 (0.75–1.1)	0.35

dissem = disseminated or combined (distant and local) failure after RT1; HR = hazard ratio; LF = local failure after RT1.