Table 1.
Comparison of Pneumococcal OPA GMTs 1 Month After PCV13+ QIV vs 1 Month After PCV13 Alone (Evaluable Immunogenicity Population).
| Vaccine Sequence (as Randomized) |
|||||
|---|---|---|---|---|---|
| PCV13+QIV, placebo | Placebo+QIV, PCV13 | Vaccine Comparison |
|||
| Serotype | na | GMTb (95% CI)c | na | GMTb (95% CI)c | Ratiod (95% CI)e |
| 1 | 419 | 75 (65.0–87.0) | 417 | 83 (71.1–96.1) | 0.9 (0.74–1.12) |
| 3 | 422 | 41 (36.2–46.0) | 418 | 49 (43.6–55.3) | 0.8 (0.70–0.98) |
| 4 | 412 | 587 (489.9–702.5) | 417 | 824 (692.2–980.0) | 0.7 (0.55–0.91) |
| 5 | 423 | 97 (83.8–111.7) | 414 | 101 (86.6–117.2) | 1.0 (0.78–1.18) |
| 6A | 420 | 953 (805.7–1126.3) | 415 | 1413 (1203.3–1659.4) | 0.7 (0.53–0.85) |
| 6B | 414 | 867 (722.3–1039.6) | 405 | 1041 (860.5–1260.0) | 0.8 (0.64–1.08) |
| 7F | 424 | 651 (582.4–728.0) | 419 | 670 (599.7–748.5) | 1.0 (0.83–1.14) |
| 9V | 419 | 699 (613.7–797.2) | 415 | 838 (734.2–957.5) | 0.8 (0.69–1.00) |
| 14 | 421 | 574 (496.8–663.0) | 416 | 760 (665.6–868.0) | 0.8 (0.62–0.92) |
| 18C | 420 | 713 (598.9–849.9) | 414 | 865 (726.4–1030.5) | 0.8 (0.64–1.06) |
| 19A | 425 | 337 (294.9–384.6) | 419 | 390 (344.4–441.1) | 0.9 (0.72–1.04) |
| 19F | 423 | 324 (274.8–382.5) | 416 | 360 (302.7–427.9) | 0.9 (0.71–1.14) |
| 23F | 421 | 278 (223.9–344.7) | 417 | 364 (294.3–451.3) | 0.8 (0.56–1.03) |
GMT = geometric mean titer; OPA = opsonophagocytic activity; PCV13 = 13-valent pneumococcal conjugate vaccine; QIV = quadrivalent inactivated influenza vaccine.
Underlined vaccine names indicate which immune response data for each study group are presented for comparison in the table.
an = Number of subjects with a determinate OPA titer to the given serotype.
bGMTs were calculated using all subjects with available data for the specified blood draw.
cCIs are back-transformations of a CI based on the Student t distribution for the mean logarithm of the titers.
dRatio of GMTs PCV13+QIV/placebo to placebo+QIV/PCV13 was calculated by back-transforming the mean difference between vaccine sequences on the logarithmic scale.
eCIs for the ratio are back-transformations of a CI based on the Student t distribution for the mean difference of the logarithms of the measures (PCV13+QIV/placebo – placebo+QIV/PCV13).